Identification of aminopiperidine benzamides as MCHr1 antagonists

Anil Vasudevan; Mary K Verzal; Derek Wodka; Andrew J Souers; Christopher Blackburn; Jennifer Lee Che; Sujen Lai; Sevan Brodjian; Doug H Falls; Brian D Dayton; Elizabeth Govek; Tom Daniels; Brad Geddes; Kennan C Marsh; Lisa E Hernandez; Christine A Collins; Philip R Kym

doi:10.1016/j.bmcl.2005.05.023

Identification of aminopiperidine benzamides as MCHr1 antagonists

Bioorg Med Chem Lett. 2005 Jul 15;15(14):3412-6. doi: 10.1016/j.bmcl.2005.05.023.

Authors

Anil Vasudevan¹, Mary K Verzal, Derek Wodka, Andrew J Souers, Christopher Blackburn, Jennifer Lee Che, Sujen Lai, Sevan Brodjian, Doug H Falls, Brian D Dayton, Elizabeth Govek, Tom Daniels, Brad Geddes, Kennan C Marsh, Lisa E Hernandez, Christine A Collins, Philip R Kym

Affiliation

¹ Metabolic Diseases Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA. anil.vasudevan@abbott.com

PMID: 15950463
DOI: 10.1016/j.bmcl.2005.05.023

Abstract

The identification of a novel series of benzamide-containing MCHr1 antagonists is described. Compound 22 displayed moderate efficacy in a diet induced obesity mice model.

MeSH terms

Administration, Oral
Animals
Anti-Obesity Agents / chemical synthesis
Anti-Obesity Agents / chemistry*
Anti-Obesity Agents / pharmacology*
Benzamides / chemical synthesis
Benzamides / chemistry*
Benzamides / pharmacology*
Binding, Competitive
Disease Models, Animal
Dogs
Mice
Molecular Structure
Piperidines / chemical synthesis
Piperidines / chemistry*
Piperidines / pharmacology*
Receptors, Somatostatin / antagonists & inhibitors*
Receptors, Somatostatin / metabolism
Structure-Activity Relationship
Time Factors

Substances

Anti-Obesity Agents
Benzamides
Piperidines
Receptors, Somatostatin